Synthesis of some pyridazinylacetic acid derivatives as a novel class of monoamine oxidase-A inhibitors.
نویسندگان
چکیده
A series of new pyridazinylacetic acid derivatives were synthesized and have been investigated for their ability to inhibit the activity of the A and B isoforms of monoamine oxidase (MAO). All compounds were found to be more selective to the MAO-A isoform with compound 5d having the highest SI values. Computational study performed with a docking technique indicated the potential of these compounds in pyridazine-based MAO-A inhibitor drug development.
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عنوان ژورنال:
- Chemical & pharmaceutical bulletin
دوره 56 12 شماره
صفحات -
تاریخ انتشار 2008